索引：GLP1类似蛋白Exendin4抗体说明书

中文名称    GLP1类似蛋白Exendin4抗体    

英文名称    Exendin 4    

别    名    Exendin 4; Exendin4; Exendin-4; EXE4_HELSU .    

供 应 商    远慕生物

研究领域    免疫学  神经生物学  糖尿病      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Gila monster lizard    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 GLP1类似蛋白Exendin4抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    4.3kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

GLP1类似蛋白Exendin4抗体产品介绍    background:

Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion.

Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the venom gland.

Similarity:
Belongs to the glucagon family.

Database links:
UniProtKB/Swiss-Prot: P26349.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.