推荐：胞吐囊复合体蛋白2抗体用途

中文名称    胞吐囊复合体蛋白2抗体  

英文名称    EXOC2      

别    名    exocyst complex component 2; exocyst complex component Sec5; FLJ11026; SEC5; SEC5 like 1; SEC5L1; Sec5p; EXOC2_HUMAN.    

供 应 商    远慕生物      

研究领域    细胞生物  转录调节因子  转运蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 胞吐囊复合体蛋白2抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    104kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EXOC2/SEC5    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

胞吐囊复合体蛋白2抗体产品介绍    background:

The mammalian exocyst complex (sec 6/8) is a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Sec 5 is one of eight exocyst complex subunits: Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84. Exocyst complex regulation depends upon Sec5 binding Ral in a GTP-dependent manner. Human Sec5 maps to chromosome 6p25.3.

Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Subunit:
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with RALA and GNEFR/DELGEF. Interaction with GNEFR occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP. Interacts with RALB.

Subcellular Location:
Plasma membrane.

Tissue Specificity:
Widely expressed with highest levels in brain and placenta.

Similarity:
Belongs to the SEC5 family.
Contains 1 IPT/TIG domain.

Database links:

Entrez Gene: 55770 Human

Entrez Gene: 66482 Mouse

Entrez Gene: 171455 Rat

SwissProt: Q96KP1 Human

SwissProt: Q9D4H1 Mouse

SwissProt: O54921 Rat

Unigene: 484412 Human

Unigene: 293510 Mouse

Unigene: 2869 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.