DISC1N端抗体使用说明书

英文名称    DISC1 (NT)   

中文名称    DISC1 N端抗体   

别    名    disrupted in schizophrenia1; C1orf136; KIAA0457; RP4-730B13.1; SCZD9; DISC1; DISC1_HUMAN.   

供 应 商    远慕生物     

研究领域    细胞生物  神经生物学  Alzheimer's     

抗体来源    Rabbit   

克隆类型    Polyclonal   

交叉反应    Human,    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 DISC1 N端抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    92kDa   

细胞定位    细胞浆 细胞膜    

性    状    Lyophilized or Liquid   

浓    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DISC1   

亚    型    IgG   

纯化方法    affinity purified by Protein A   

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide   

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

DISC1 N端抗体产品介绍    background:

DISC1 (disrupted in schizophrenia 1) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is a multifunctional protein that is involved in neurite outgrowth and cortical development, through its interaction with proteins of the centrosome and cytoskeletal system, and is implicated in schizophrenia. Regions of the primate brain which express DISC1, including the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, are reported to be involved in schizophrenia in humans.

Function:
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.