脑表皮生长因子跨膜蛋白DNER抗体用途

英文名称    DNER   

中文名称    脑表皮生长因子跨膜蛋白DNER抗体   

别    名    Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; Delta/notch-like EGF-related receptor; Dner; DNER_HUMAN; PRO299; Transmembrane protein Bet; UNQ26.   

供应商     远慕生物  

研究领域    神经生物学  信号转导  干细胞  细胞表面分子     

抗体来源    Rabbit   

克隆类型    Polyclonal   

交叉反应    Human, Mouse, Rat, Dog, Cow, Sheep,    

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 脑表皮生长因子跨膜蛋白DNER抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    75kDa   

细胞定位    细胞浆 细胞膜    

性    状    Lyophilized or Liquid   

浓    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DNER   

亚    型    IgG   

纯化方法    affinity purified by Protein A   

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

脑表皮生长因子跨膜蛋白DNER抗体产品介绍    background:

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.

Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Subunit:
Interacts with AP1G1. Interacts with NOTCH1 (By similarity).

Subcellular Location:
Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.

Tissue Specificity:
Expressed in brain, spinal cord and adrenal gland.

Similarity:
Contains 10 EGF-like domains.
Contains 1 follistatin-like domain.

Database links:
UniProtKB/Swiss-Prot: Q8NFT8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.